Jesus spent His final 40 days on earth teaching His disciples about the Kingdom of God and preparing them for their future ministry. He instructed them to wait in Jerusalem for the Holy Spirit's empowerment before beginning their work. The disciples were called to be witnesses in challenging locations - Jerusalem, Judea, Samaria, and beyond - demonstrating that God often leads us to difficult places while providing His Spirit's power to minister effectively. This teaching emphasizes the importance of relying on the Holy Spirit's guidance rather than our own strength.